Correct interpretation of the data from integral laboratory tests, including Thrombin Generation Test, requires biochemistry-based mathematical models of blood coagulation. The purpose of this study is to describe the experimental TGT data from healthy donors and hemophilia A and B patients. We derive a simplified ODE model and apply it to analyze the TGT data from healthy donors and HA/HB patients with in vitro added tissue factor pathway inhibitor antibody. This model allows the characterization of hemophilia patients in the space (...) of three most important model parameters. The proposed approach may provide a new quantitative tool for the analysis of experimental TGT. Also, it gives a reduced model of coagulation verified against clinical data to be used in future theoretical large-scale modeling of thrombosis in flow. (shrink)

A 4-space formulation of Dirac's equation gives results formally identical to those of the usual Klein paradox. However, some extra physical detail can be inferred, and this suggests that the most extreme case involves pair production within the potential barrier.

Or a Treatise on Language. ... oironff inclination for na : this is one of the most s s language exposes'*! ... cs- •al, enables me to gratify my unenviable propensity. , Among the results is a Treatise on the Philosophy of / Human Knowledge.

On the life and philosophy of Bhāskarācārya, 8th cent., Vedanta philospher and commentator of Brahmasūtra.

Without a doubt, one of the main reasons Platonsim remains such a strong contender in the Foundations of Mathematics debate is because of the prima facie plausibility of the claim that objectivity needs objects. It seems like nothing else but the existence of external referents for the terms of our mathematical theories and calculations can guarantee the objectivity of our mathematical knowledge. The reason why Frege – and most Platonists ever since – could not adhere to the idea that mathematical (...) objects were mental, conventional or in any other way dependent on our faculties, will or other historical contingencies was that objects whose properties of existence depended on such contingencies could not warrant the objectivity required for scientific knowledge. This idea gained currency in the second half of the 19th Century and remains current for the most part today. However, it was not always like that. Objectivity, after all, has a history, and according to its historians (Daston 2001), the view that scientific knowledge need be objective is a fairly recent one. Up until mid-19th Century, science was not so much concerned with objectivity, as it was concerned with truth. Before the rise of the modern university and the professional scientist, science had the discovery of truths as its ultimate goal. In contrast, modern science now aims at the production and acquisition of objective knowledge. The difference might seem.. (shrink)

This book is a study of the second-edition version of the 'Transcendental Deduction', which is one of the most important and obscure sections of Kant's Critique of Pure Reason. By way of a close analysis of the B-Deduction, Adam Dickerson makes the distinctive claim that the Deduction is crucially concerned with the problem of making intelligible the unity possessed by complex representations - a problem that is the representationalist parallel of the semantic problem of the unity of the proposition. Along (...) the way he discusses most of the key themes in Kant's theory of knowledge, including the nature of thought and representation, the notion of objectivity, and the way in which the mind structures our experience of the world. (shrink)

Following lesions to the primary visual cortex, some patients maintain visual capacities within areas of the visual field in which they are defined as clinically blind by static field perimetry. Blindsight describes the ability to discriminate visual stimuli in the absence of awareness of the stimuli in such patients. Some patients exhibit blindsight, but others are aware of the stimuli with which they are presented, a response mode that has been referred to as residual vision. The two response modes are (...) of great interest as they are capable of providing us with information concerning the conscious and unconscious processing of visual signals in humans. However, determining consciousness in these patients is a difficult task and relies on the patient assessing and then reporting on his awareness. In this paper, an experiment is described which is capable of demonstrating conscious visual processing of motion under conditions where the observer is not required to assess his level of awareness. In applying this technique to a human hemianope, GY, it is demonstrated that GY has veridical and conscious perception of visual motion presented to his blind hemifield. Although previously reported, this result can be derived without any reference to GY's commentary on his blind field perception. (shrink)

A new theory of particles proposed in an earlier paper is now applied to explain energy. Having earlier derived the Rydberg formula for atomic spectra without using the Pauli principle, the authors now derive the photoelectric effect, deflection of light by gravitation, and Planck's law for blackbody radiation without using Planck's assumption on energy quanta or Einstein's theory of general relativity.